Sr. Director, Process Chemistry
Location: Indianapolis
Posted on: June 23, 2025
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Job Description:
At Lilly, we unite caring with discovery to make life better for
people around the world. We are a global healthcare leader
headquartered in Indianapolis, Indiana. Our employees around the
world work to discover and bring life-changing medicines to those
who need them, improve the understanding and management of disease,
and give back to our communities through philanthropy and
volunteerism. We give our best effort to our work, and we put
people first. We’re looking for people who are determined to make
life better for people around the world. Organizational Overview:
The Synthetic Molecule Design and Development (SMDD) team is
involved in key activities for the development of synthetic active
pharmaceutical ingredients (API) from pre-clinical phases through
commercialization of drug substances and drug products. Our
chemists, engineers, and scientists develop key technical and
business solutions across the portfolio using their deep technical
expertise to accelerate testing of the clinical hypothesis and
overall drug development. SMDD delivers on these responsibilities
by recognizing diverse talent and cultures are vital to bring the
next generation of life changing medicines to patients. Position
Summary: Our team is looking for experienced and creative
individuals to lead synthetic molecule route commercialization as
well as process optimization and unit operation definition of drug
candidates to support clinical trials, product commercialization,
and regulatory submissions. The position presents an opportunity to
lead dynamic teams comprised of process chemists, analytical
chemists, formulation scientists, and engineers. Additionally,
candidates will provide oversight for external R&D, tech
transfer, and campaign execution. Responsibilities: Demonstrate a
deep expertise and demonstrated capability with utilization of
modern synthetic organic and process chemistry techniques to
address key CMC challenges Lead and/or supervise the design and
development of new synthetic routes for the manufacture of API
using the most modern technologies Exhibit a high learning agility
with the ability to understand and exploit new scientific concepts
and methods across multiple fields; be able to apply these
takeaways to a portfolio of small molecule, oligonucleotide, and
synthetic peptide, and other emerging synthetic modalities Possess
solid understanding in unit operation design, process modeling,
process equipment selection, and scale-up methodologies; build and
apply groundbreaking technology and novel platforms within a time
constrained environment Lead a cross-disciplinary team to evaluate
and refine new manufacturing routes, manufacturing technologies,
and practices to deliver an exciting portfolio Provide technical
leadership in the scale-up and demonstration of new chemical
processes in development and commercial scale equipment;
collaborate in technology transfer activities to CRO/CMO
organizations and internal Lilly manufacturing nodes to ensure
processes are technically robust, well developed and characterized,
and safe Design experimental laboratory plans in support of route
and process design, definition, optimization, and technology
transfer objectives. Ability to integrate process (and property
design) data based on a fundamental understanding of the underlying
physical processes Apply advancements in technology (PAT) and
modeling platforms to understand and lead experimental protocols.
Leverage high throughput experimental platforms to accelerate
reaction discovery. Plan and lead short term and long-term
development activities; develop and/or review technical agendas and
timelines for project work; advise resource allocation to
accomplish projects according to plans, communicate progress and
propose changes in timeline, objectives, or direction. Collaborate
across internal CMC networks (Drug Product Delivery, Project
Management, Quality, Manufacturing, and Regulatory) to implement
and deliver material and information for clinical trials and
regulatory submissions. Possess deep understanding of the external
global regulatory climate and emerging requirements; ability to
address key CMC regulatory questions that enable clinical studies
and support marketing authorization applications Embrace diversity
in thoughts, background, and experiences through supervision,
mentoring, and development of a diverse scientific staff to deliver
solutions. Encourage team members to take initiative and
accountability to achieve goals and draw out and encourage others
to share knowledge on challenging technical issues Actively
collaborate and exhibit influence in the external scientific
environment and demonstrates an ability to recognize and integrate
external innovation across the Lilly synthetic portfolio Minimum
Qualifications: Ph.D. in organic chemistry, or a related field with
10 years of pharmaceutical process development experience OR MS in
Organic Chemistry or related field with 15 years' experience.
Additional Skills/Preferences: Experience within the pharmaceutical
sector is preferred; however, other experience may meet
expectations. Prior experience in active ingredient development and
associated formulated product is acceptable. Relevant industrial
sectors would include agrochemicals, nutraceuticals, specialty
chemicals, and personal care products. Experience with developing
chemical processes from mid-development cycle (proof of concept) to
product commercialization. Experience with technical transfer of
processes into manufacturing operations Experience with authoring
regulatory submissions and responding to regulatory questions
Established external reputation and strong publication record
Knowledge and experience with management of a technical project and
ability to build ideas for future work plans Experience with modern
analytical techniques and process analytical technologies (PAT)
Experience with modeling and simulation tools, data analytics, and
predictive analytics Ability to transform ideas into marketable
products and processes Demonstrated leadership capabilities, good
communication skills and a sustained tendency for collaboration
Ability to prioritize multiple activities and handle ambiguity
Ability to influence others to promote a positive work environment
Additional Information: Potential exposure to chemicals, allergens,
and loud noises. Travel: 0 to 10% Position Location: Indianapolis,
IN; Lilly Technology Center-North (LTC-N) Lilly is dedicated to
helping individuals with disabilities to actively engage in the
workforce, ensuring equal opportunities when vying for positions.
If you require accommodation to submit a resume for a position at
Lilly, please complete the accommodation request form (
https://careers.lilly.com/us/en/workplace-accommodation ) for
further assistance. Please note this is for individuals to request
an accommodation as part of the application process and any other
correspondence will not receive a response. Lilly is proud to be an
EEO Employer and does not discriminate on the basis of age, race,
color, religion, gender identity, sex, gender expression, sexual
orientation, genetic information, ancestry, national origin,
protected veteran status, disability, or any other legally
protected status. Our employee resource groups (ERGs) offer strong
support networks for their members and are open to all employees.
Our current groups include: Africa, Middle East, Central Asia
Network, Black Employees at Lilly, Chinese Culture Network,
Japanese International Leadership Network (JILN), Lilly India
Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ
Allies), Veterans Leadership Network (VLN), Women’s Initiative for
Leading at Lilly (WILL), enAble (for people with disabilities).
Learn more about all of our groups. Actual compensation will depend
on a candidate’s education, experience, skills, and geographic
location. The anticipated wage for this position is $139,500 -
$246,400 Full-time equivalent employees also will be eligible for a
company bonus (depending, in part, on company and individual
performance). In addition, Lilly offers a comprehensive benefit
program to eligible employees, including eligibility to participate
in a company-sponsored 401(k); pension; vacation benefits;
eligibility for medical, dental, vision and prescription drug
benefits; flexible benefits (e.g., healthcare and/or dependent day
care flexible spending accounts); life insurance and death
benefits; certain time off and leave of absence benefits; and
well-being benefits (e.g., employee assistance program, fitness
benefits, and employee clubs and activities).Lilly reserves the
right to amend, modify, or terminate its compensation and benefit
programs in its sole discretion and Lilly’s compensation practices
and guidelines will apply regarding the details of any promotion or
transfer of Lilly employees. WeAreLilly
Keywords: , Indianapolis , Sr. Director, Process Chemistry, Science, Research & Development , Indianapolis, Indiana
