Postdoctoral Scientist (R0) – Epigenetics and Multi-Omics in Psychiatry

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: February 26, 2026

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Lilly Neuroscience is seeking a highly motivated postdoctoral scientist to join the Pain and Neuronal Health discovery biology group to advance our mission of discovering novel therapeutics for psychiatric and brain-related disorders. We are looking for a computational scientist with expertise in epigenetics, multi-omic data integration, and systems biology approaches to elucidate the molecular mechanisms underlying psychiatric conditions. You should be passionate about applying cutting-edge computational methods to understand the epigenetic and molecular architecture of brain disorders, with particular focus on integrative multi-omics analyses, network and pathway modeling, and translational bioinformatics. The ideal candidate will possess exceptional scientific rigor, a deep interest in psychiatric disease biology, and strong collaborative skills to work across multidisciplinary teams. Are you ready to make a meaningful impact in psychiatric research and contribute to the discovery of life-changing medicines for patients? This could be the opportunity for you. Your Key Responsibilities Will Include Epigenetic Analyses & Multi-Omics Integration Network and Pathway Analyses Collaborative Research and Translational Impact Basic Qualifications PhD in bioinformatics, computational biology, genomics, neuroscience, biostatistics, or a related quantitative discipline Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1 Additional Skills/Preferences Strong publication record demonstrating expertise in epigenetics, multi-omics analysis, or systems biology Proficiency in programming languages such as R and Python with experience in relevant bioinformatics libraries (Bioconductor, scikit-learn, PyTorch, etc.) Demonstrated experience with NGS data analysis, including epigenomic datasets (ChIP-seq, ATAC-seq, bisulfite sequencing, methylation arrays) Experience with multi-omic data integration approaches and network/pathway analysis methods Strong understanding of statistical methods, experimental design, and hypothesis testing Familiarity with high-performance computing environments, workflow management systems, and version control Expertise in psychiatric genetics, neuroscience, or brain-related disorders Experience analyzing human brain tissue datasets, psychiatric cohorts, or relevant disease models Knowledge of psychiatric GWAS, eQTL, and functional genomics studies Experience with machine learning and deep learning methods applied to biological data Familiarity with single-cell and spatial multi-omics technologies and analysis methods Experience with biological databases and resources (GTEx, PsychENCODE, CommonMind Consortium, UK Biobank, gnomAD, ENCODE, Roadmap Epigenomics, etc.) Track record of collaborative, interdisciplinary research Excellent written and oral communication skills with ability to present complex computational findings to diverse audiences Prior experience in pharmaceutical or biotech industry is a plus Strong organizational skills and ability to manage multiple projects simultaneously Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $58,000 - $123,200 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

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